Chemokine receptors as important regulators of pathogenesis during arboviral encephalitis
"The central nervous system (CNS) is a highly complex network comprising long-lived neurons and glial cells. Accordingly, numerous mechanisms have evolved to tightly regulate the initiation of inflammatory responses within the brain. Under neuroinflammatory conditions, as in the case of viral encephalitides, the infiltration of leukocytes is often required for efficient viral clearance and recovery. The orchestration of leukocyte migration into the inflamed CNS is largely coordinated by a large family of chemotactic cytokines and their receptors." – Frontiers in Cellular Neuroscience (September 30, 2014)
I provided 3 illustrations focusing on the dual role of CCR2-expressing monocytes during a West Nile virus (WNV) infection, the role of CCR5 during flavivirus-induced encelphalitis, and the role of CXCR3 and CXCR4 during arbovirus-induced encephalitis in mice.
Mount Sinai Hospital, New York